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The mechanism by which Klotho induces antioxidant factors and provides subsequent oxidative protection may involve a multitude of factors and pathways

The dose may be increased in 2.5 mg increments every 4 weeks, based on clinical response and tolerability, up to a maximum of 15 mg (1.5 mL) per week

With the development of IR, an unfavorable, reverse flux of FFAs toward non-adipose tissues, such as the liver, occurs

Participants had structured dietary support, regular check-ins, and controlled environments